25-Hydroxyvitamin D in the Range of 20 to 100 ng/mL and Incidence of Kidney Stones
Stacie Nguyen, MPH, Leo Baggerly, PhD, Christine French, MS, Robert P. Heaney, MD, Edward D. Gorham, PhD, and Cedric F. Garland, DrPH
Objectives: Increasing 25-hydroxyvitamin D serum levels can prevent a wide range of diseases. There is a concern about increasing kidney stone risk with vitamin D supplementation. We used GrassrootsHealth data to examine the relationship between vitamin D status and kidney stone incidence. Methods. The study included 2012 participants followed prospectively for a median of 19 months. Thirteen individuals self-reported kidney stones during the study period. Multivariate logistic regression was applied to assess the association between vitamin D status and kidney stones.
Results: We found no statistically significant association between serum 25-hydroxyvitamin D and kidney stones (P = .42). Body mass index was significantly associated with kidney stone risk (odds ratio = 3.5; 95% confidence interval = 1.1, 11.3).
Conclusions: We concluded that a serum 25-hydroxyvitamin D level of 20 to 100 nanograms per milliliter has no significant association with kidney stone incidence.
Dimensions: 8.5 x 11 inches